- Combination of layer Paper/ Polyethylene terephthalate (PET) /Aluminium /heat seal lacquer
- Take the sample of a combination layer paper/ Polyethylene terephthalate (PET)/aluminium/Heat seal lacquer. Cut the sample of 10 x 10 cm with the help of a GSM plate. Take the Weight of an analytical balance.
- Total GSM = weight of sample in gram x 100 (if the sample cut out 10 x 10 cm )=G
- Dip the cotton in ethyl acetate and rub the sample on the HSL Coating Layer side remove the coating dry the sample at room temperature and take the weight of the sample.
- GSM OF REMAINING SAMPLE = weight in gram x 100 (if the sample is cut 10 x 10 cm)=G1
- Grammage of HSL Layer = G-G1
- Take the remaining sample and immerse the sample in a beaker containing hot water for 30 min. use a clean cloth to remove a paper layer from the aluminium layer. Weight the sample at analytical balance.
- Grammage of GSM = Weight of sample in gram x 100 (if the sample is cut out 10 x 10 cm )=G2
- Grammage of paper layer = G1-G2
- Take after separating the paper immersed in boiling 25 % solution of glacial acetic acid and water. Kept the sample for 5 min and checked the separation of Polyethylene terephthalate (PET) and Aluminium foil. if the sample did not separate the layer the sample again boiled the solution till separation the layer for 10- 15 min. separation of both layers dried in the layer oven at 750c for 2 min. then take the weight
- Grammage of PET Layer = weight in gram x 100
- Grammage of Aluminium Layer = weight in gram x 100.
I am Maneesh Maurya a professional pharmaceutical blogger from India having rich experience in the pharmaceutical Quality control field.
